Research Studies 2020-03-05T16:42:50-05:00

AUGM RESEARCH

Evidenced-based Medicine

Research studies at AUGM

  • Khandwala S, Cruff J. A novel method of pudendal nerve blockade for managing pain following vaginal reconstructive surgery. Journal of Gynecologic Surgery 2020 [Ahead of Print].

    Khandwala S, Cruff J. Single-incision sling procedure done by the Dynamic Intraoperative Standing Sling Technique: a 2-year analysis. Journal of Gynecologic Surgery 2019 [Ahead of Print].

    Kobashi K, Nitti V, Margolis E, Sand P, Siegel S, Khandwala S, Newman D, MacDiarmid SA, Kan F, Michaud E. A prospective study to evaluate efficacy using the Nuro Percutaneous Tibial Neuromodulation System in drug-naïve patients with overactive bladder syndrome. Urology 2019 Sep; 131: 77-82.

    Khandwala S. Transvaginal mesh surgery for pelvic organ prolapse: one-year outcome analysis. Journal of Gynecologic Surgery 2019; 35(1): 12-18.

    Cruff J, Khandwala S. Two cases of obstructive uropathy in patients with advanced pelvic organ prolapse. Journal of Gynecologic Surgery 2019; 35(1): 60-3.

    Khandwala S, Williams C, Reeves W, Dai J, Jayachandran C. Role of vaginal mesh hysteropexy for the management of advanced uterovaginal prolapse. The Journal of Reproductive Medicine 2014: 59: 371-8.

    Khandwala S. Transvaginal mesh surgery for pelvic organ prolapse: one-year outcome analysis. Female Pelvic Medicine and Reconstructive Surgery 2013 Mar-Apr; 19(2): 84-9.

    Visco AG, Brubaker L, Richter HE, Nygaard I, Paraiso MF, Menefee SA, Schaffer J, Lowder J, Khandwala S, Sirls L, Spino C, Nolen TL, Wallace D, Meikle SF, Pelvic Floor Disorders Network. Anticholinergic therapy vs. onabotulinumtoxin A for urgency urinary incontinence. The New England Journal of Medicine 2012 Nov 8; 367(19): 1803-13.

    Khandwala S, Jayachandran C. TVT-Secur in office sling procedure under local anesthesia: a prospective 2-year analysis. Female Pelvic Medicine and Reconstructive Surgery 2012 Jul-Aug; 18(4): 233-8.

    Nager CW, Brubaker L, Litman HJ, […] Khandwala S, […] Gormley EA, Urinary Incontinence Treatment Network. A randomized trial of urodynamic testing before stress-incontinence surgery. The New England Journal of Medicine 2012 May 24; 366(21): 1987-97.

    Milani AL, Hinoul P, Gauld J, Jones P, Reisenauer C, Lobodasch K, Cosson M, Khandwala S, Van Drie D, Lucente V. Medium-term clinical outcomes following trocar-guided mesh repair of vaginal prolapse using partially absorbable mesh. 2012 (abstract) International Urogynecologic Association (IUGA).

    Tincello DG, Botha T, Grier D, Jones P, Subramanian D, Urquhart C, Kirkemo A, Khandwala S; TVT Worldwide Registry Investigators. The TVT worldwide registry for long-term data: safety and efficacy of suburethral sling insertion approaches for stress urinary incontinence in women. The Journal of Urology 2011 Dec; 186(6): 2310-5.

    Khandwala S, Jayachandran C. Transvaginal mesh surgery for pelvic organ prolapse-Prolift+M: a prospective clinical trial. International Urogynecology Journal 2011 Nov; 22(11): 1405-11.

    Urquhart C, Hinoul P, Milani A, Reisenauer C, Cosson M, Lucente V, Khandwala S. Two year clinical outcomes of a trocar-guided transvaginal mesh repair utilizing a new light-weight synthetic mesh. 2011 (abstract) International Urogynecologic Association (IUGA).

    Van Drie D, Lim JL, Hinoul P, Gauld J, Sayer TR, Jones P, Franco N, Slack M, Khandwala S. Medium-term clinical outcomes following surgical repair for vaginal prolapse with a tension-free mesh and vaginal support device. Female Pelvic Medicine and Reconstructive Surgery 2011 Sept/Oct; 17(5) Supplement 2 and International Urogynecologic Association (IUGA) 2011.

    Khandwala S, Lucente V, Van Drie D, Gauld J, Hinoul P. Clinical outcomes of an observational registry utilizing a trocar-guided mesh repair of vaginal prolapse using partially absorbable mesh. Female Pelvic Medicine and Reconstructive Surgery 2011 Sept/Oct; 17(5) Supplement 2.

    Khandwala S, Slack M, Hinoul P, Urqhart C, Al-Salihi S. A trocar-free procedure for vaginal prolapse repair using mesh and a vaginal support device-an observational registry. Female Pelvic Medicine and Reconstructive Surgery 2011 Sept/Oct; 17(5) Supplement 2.

    Milani A, Hinoul P, Gauld J, Sikirica V, Van Drie D, Cosson M, Khandwala S. Trocar guided mesh repair for vaginal prolapse using partially absorbable mesh: 1 year outcomes. American Journal of Obstetrics and Gynecology 2011 Jan; pp 74.e1-74.e8 vol 204(1).

    Richter HE, Albo ME, Zyczynski HM, […] Khandwala S, […] Litman HJ; Urinary Incontinence Treatment Network. Retropubic versus transobturator midurethral slings for stress incontinence. The New England Journal of Medicine 2010 Jun 3; 362(22): 2066-76.

    Khandwala S, Jayachandran C, Sengstock D. Experience with TVT-SECUR sling for stress urinary incontinence: a 141-case analysis. International Urogynecology Journal 2010 Jul; 21(7): 767-72.

    Zyczynski H, Carey M, Smith A, Gauld J, Robinson D, Sikirica V, Reisenauer C, Slack M, Khandwala S. American Journal of Obstetrics and Gynecology 2010 Dec; pp 587.e1-587.e8 vol 203(6).

    Khandwala S, Lucente V, Tincello, et al. One year results from a worldwide registry of Tension free vaginal tapes in women with stress urinary incontinence. Female Pelvic Medicine and Reconstructive Surgery 2009 Sept/Oct; pp 261 vol 12(5).

    Lucente V, Milani A, Khandwala S, et al. Light weight mesh system for transvaginal mesh repair: interim 3 month results. Female Pelvic Medicine and Reconstructive Surgery 2009 Sept/Oct; pp 359 vol 12(5).

    Carey M, Zyczynski H, Khandwala S, et al. Clinical Experience of a novel vaginal support device and balloon used in a trocar-less vaginal approach of mesh placement for prolapse repair. Female Pelvic Medicine and Reconstructive Surgery 2009 Sept/Oct; pp 364 vol 12(5).

    Burgio KL, Kraus SR, Menefee S, […] Khandwala S, […] Steers W; Urinary Incontinence Treatment Network. Behavioral therapy to enable women with urge incontinence to discontinue drug treatment: a randomized trial. Annals of Internal Medicine 2008 Aug 5; 149(3): 161-9.

National Institute of Health (NIH) Clinical studies performed at AUGM

  • A Randomized Trial of Urodynamic Tests Before Stress Incontinence Surgery.
    Nager, C., Brubaker, L., Litman, H., Zyczynski, H., Varner, R., et al. The New England Journal of Medicine.

    This paper assesses the role of urodynamic testing for patients with incontinence.

  • Urinary Incontinence Treatment Network – MIMOSA study- NIH-sponsored multicentric randomized clinical trial to compare medication and behavioral therapy versus surgery for mixed urinary incontinence

    This study aimed to assess the impact of pelvic floor therapy versus medications on the management of overactive bladder conditions

  • Behavioral therapy to enable women with urge incontinence to discontinue drug treatment: a randomized trial.
    Ann Intern Med. 2008;149(3):161-9.
    BE-DRI (Behavior Enhances Drug Reduction of Incontinence)

    This study investigated if the addition of behavioral treatment to drug therapy for the treatment of urge incontinence makes it possible to discontinue the drug and still maintain a reduced number of accidents.

  • ValUE study

    The ValUE Study is designed to determine the appropriate amount of pre-surgical urinary testing that is necessary for a patient.

  • Anticholinergic versus Botulism toxin-a comparison trial for the treatment of urgency urinary incontinence: the ABC randomized trial

    Visco AG, Brubaker L, Richter HE, Nygaard I, Paraiso MF, Menefee SA, Schaffer J, Lowder J, Khandwala SS, Sirls L, Spino C, Wallace D, Meikle S for the Pelvic Floor Disorders Network (NIH)

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TOMUS (Trial Of Mid-Urethral Slings)

Trial of Midurethral Sling (TOMUS): A Randomized Controlled Trial of Retropubic versus Transobturator Midurethral sling for stress urinary incontinence New Engl J of Medicine. 2010 Jun 3;362(22):2066-76

Trial of Midurethral Sling (TOMUS): Design and Methodology Journal of Applied Research Vol 8, no 1, 2008.

The TOMUS trial is a randomized study comparing the retropubic sling to the transobturator sling for the management of stress urinary incontinence. This was a National Institute of Health study. The study was conducted by several centers across the country. The results showed that the trans-obturator system is comparable to the retropubic system. Stringent subjective and objective criteria were use to determine success following the surgical intervention. Complications with both the procedures were minimal and comparable.

Ongoing Clinical Trials at AUGM

  • Follow up on patients with the suburethral mini sling procedure for urinary incontinence — a long term follow up

    This study reviews all the patients who have had the third generation sling procedure and reviews the complications, success and failures.

  • Role of Interstim for the management of fecal incontinence

    This paper assesses the subjective success of the Interstim procedure in patients suffering from fecal incontinence.

  • Is hysterectomy necessary for the management of uterovaginal prolapse? The role of uterine preservation – a retrospective analysis of 126 cases

    This study looks at the ability to preserve the uterus at prolapse surgery. Patients with prolapse of the cervix greater than stage II were considered for the study.

  • A comparison of in office and operating room sling procedure for the management of urinary incontinence

    This study looks to see if there are any risks or differences in doing the procedure in the office as compared to the operating room.

  • Long term follow up of vaginal reconstructive surgery for uterovaginal prolapse — reviewing the role of Prolift + M surgery

    Patients who underwent Prolift + m surgery for prolapse and were at least 12 months out are considered for the outcome analysis.

  • Pelvic floor therapy for the management of incontinence

    Patients who underwent pelvic floor therapy for incontinence management are surveyed by way of validated questionnaires prior to and after the intervention.

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Research:

Pursuit of Excellence through
Evidence-based Medicine

At AUGM we strongly believe in practicing Evidence-based Medicine. Therefore, we constantly publish and gather scientific data. We have had several publications over the years. The list of our publications with a synopsis is available here.